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Mesenchymal stem cells can be obtained from a wide variety of human tissue, however the biggest amount of cells can be obtained from the umbilical cord blood and adipose tissue.
Benefits of Adipose Tissue Mesenchymal Stem Cells:
- In comparison to red bone marrow or peripheral blood stem cells extraction procedures, adipose tissue mesenchymal cell extraction procedure is fast, convenient and effective.
- The obtained number of stem cells is higher than that of other stem cell sources.
- These particular stem cells have a high potential for proliferation, which means that these cells can be multiplied in laboratory conditions for therapeutic purposes.
- These cells secrete cytokines, various growth factors, extracellular matrix remodelling factors, hyaluronic acid, collagen, elastin, glycosaminoglycans, and other factors that contribute to tissue regeneration.
- These cells are able to develop into osteocytes, chondrocytes and adipocytes, which form bone tissue, cartilage and muscle tissue.
Treatment that Helps with Different Health Problems!
Use of Adipose Tissue Mesenchymal Stem Cells:
- As a treatment for reducing heart attack after-effects and a treatment for myocardial infarction.
Mesenchymal stem cells notably improve myocardial infraction symptoms, as well as completely prevent or significantly reduce adverse outcome risks, help with heart muscle failure (cardiomyopathy), and generally improve the heart rate. It is important to note that this treatment cannot be used as a mono therapy, and depending on the severity of the particular disease, it can be prescribed as an additional treatment or a part of the rehabilitation process. (Joaquim Bobi, Intracoronary Administration of Allogeneic Adipose Tissue–Derived Mesenchymal Stem Cells Improves Myocardial Perfusion But Not Left Ventricle Function, in a Translational Model of Acute Myocardial Infarction, JAHA – Journal of the American Heart Association, 3.05.2017)
- As a treatment for psoriasis, especially when standard therapy methods prove to be ineffective or they do not provide the desired result
- In dermatology and plastic surgery as a treatment for burns, scars, wounds, wrinkles and signs of ageing
- As a part of rehabilitation and regeneration for the treatment of strokes of varying severity
- As a treatment for professional athletes and people who do sports on a daily basis - for various types of joint injuries (knees, elbows and recovery after BMJ) (Julien Freitag, et all. Effect of autologous adipose-derived mesenchymal stem cell therapy in the treatment of a post-traumatic chondral defect of the knee, BMJ Case Reports 2017)
- As an alternative method for the treatment of rheumatoid arthritis and osteoarthritis (Ling Kong, et all.Role of mesenchymal stem cells in osteoarthritis treatment, Journal of Orthopaedic Translation (2017) 9, 89-103)
- As a treatment for diabetes (Trivedi HL et all. Human adipose tissue-derived mesenchymal stem cells combined with hematopoietic stem cell transplantation synthesize insulin. Transplant Proc. 2008 May;40(4):1135-9)
- As a part of a treatment for pulmonary fibrosis, where alveoli becomes scarred and stiff making it difficult for the patient to breathe and lead a normal life
- As a treatment for neurodegenerative diseases
- As a treatment for a herniated disk (Junseok W. Hur et. all Intrathecal transplantation of autologous adipose-derived mesenchymal stem cells for treating spinal cord injury: A human trial, J Spinal Cord Med. 2016 Nov; 39(6): 655–664.)
- As a treatment for multiple sclerosis (Oscar Fernandez et all. Adipose-derived mesenchymal stem cells (AdMSC) for the treatment of secondary-progressive multiple sclerosis: A triple blinded, placebo controlled, randomized phase I/II safety and feasibility study. PLOS, 16,05, 2018)
In addition, it can be used as a treatment for various diseases, which are at different stages of clinical trials.